2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N3193
    Neritaloside 465-13-4 98%
    Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect[2.
    Neritaloside
  • HY-N3320
    Marmin 14957-38-1 98%
    Marmin is a coumarin, that can be isolated from the immature bark of Aegle marmelos Correa. Marmin antagonizes the Histamine (HY-B1204)-induced contraction in competitive manner.
    Marmin
  • HY-N3393
    Lethedioside A 221289-31-2 98%
    Lethedioside A is an Enhancer of split 1 (Hes1) dimer inhibitor with an IC50 value of 9.5 μM.
    Lethedioside A
  • HY-N3478
    Isohyenanchin 19417-00-6 98%
    Isohyenanchin (Hydroxycoriatin) is an RDLac homo-oligomers antagonist. Isohyenanchin also is a weak antagonist of ionotropic GABA receptors.
    Isohyenanchin
  • HY-N3482
    Isogarciniaxanthone E 659747-28-1 98%
    Isogarciniaxanthone E (compound 1) is a natural product that can be found in Garcinia xanthochymus. Isogarciniaxanthone E enhances nerve growth factor-mediated neurite outgrowth.
    Isogarciniaxanthone E
  • HY-N3489
    Isodihydrofutoquinol B 62499-71-2 98%
    Isodihydrofutoquinol B (compound 9), an active compound, can be isolated from the stems of Piper kadsura (Choisy) Ohwi. Isodihydrofutoquinol B has A neuroprotective effect on Aβ25-35-induced PC12 cell damage with E50 values of 3.06-29.3μM.
    Isodihydrofutoquinol B
  • HY-N3532
    Cannabisin F 163136-19-4 98%
    Cannabisin F is a SIRT1 modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2.
    Cannabisin F
  • HY-N3624
    Coriatin 91653-75-7 98%
    Coriatin can be isolated from L. parasiticus and has antischizophrenia activity.
    Coriatin
  • HY-N3646
    Cudratricusxanthone A 740810-42-8 98%
    Cudratricusxanthone A is isolated from Cudrania tricuspidata, and has anti-inflammatory, hepatoprotective, and anti-proliferative activities. Cudratricusxanthone A inhibits osteoclast differentiation and function in RAW 264.7 cells and mouse bone marrow monocytes.
    Cudratricusxanthone A
  • HY-N3711
    Dehydrocrenatine 26585-13-7 98%
    Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects.
    Dehydrocrenatine
  • HY-N3734
    Deoxyneocryptotanshinone 27468-20-8 98%
    Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research.
    Deoxyneocryptotanshinone
  • HY-N3883
    Euxanthone 529-61-3 98%
    Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities.
    Euxanthone
  • HY-N3894
    Ferulamide 61012-31-5 98%
    Ferulamide is a Ferulic acid derivative isolated from Portulaca oleracea L. with anticholinesterase activities.
    Ferulamide
  • HY-N3928
    Garciniaxanthone E 173294-74-1 98%
    Garciniaxanthone E is a xanthone compound. Garciniaxanthone E significantly enhances cellular nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells. Garciniaxanthone E contributes to basic research and medicinal development in neurodegenerative diseases.
    Garciniaxanthone E
  • HY-N3938
    Gelsemiol 110414-77-2 98%
    Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells.
    Gelsemiol
  • HY-N3943
    Glabrene 60008-03-9 98%
    Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC50 of 3.5 μM.
    Glabrene
  • HY-N3970
    Gopherenediol 916236-79-8 98%
    Gopherenediol is a diterpenoid with putative antifeedant activity against Mammalian herbivores. Gopherenediol is the active compound in to form deterrent effect, protects gopherweed, Euphorbia lathyris (Euphorbiaceae) from feeding by Mammalian herbivores.
    Gopherenediol
  • HY-N4016
    Ikshusterol 3-O-glucoside 112137-81-2 98%
    Ikshusterol 3-O-glucoside is a phytochemical that inhibits PLA2 from snake venoms.
    Ikshusterol 3-O-glucoside
  • HY-N4027
    Hydrangenol 8-O-glucoside 67600-94-6 98%
    Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be isolated from Hydrangea macrophyllu. Hydrangenol 8-O-glucoside is an AChE inhibitor (IC50: 22.66 μM). Hydrangenol 8-O-glucoside inhibits passive cutaneous anaphylaxis (PCA) reaction.
    Hydrangenol 8-O-glucoside
  • HY-N4161
    Euparin 532-48-9 ≥99.0%
    Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects.
    Euparin
Cat. No. Product Name / Synonyms Application Reactivity